![]() Generally, male fertility is assessed using semen analysis semen tests are based on diagnostic methods in line with the WHO criteria and include analysis of semen volume, sperm concentration, total sperm count, sperm motility, and sperm malformation rate. However, many reports have shown that male factors also affect the success or failure of IVF, indicating that male examination is important for assessing fertility in couples. Therefore, it is important to focus on DFI measurements.įemale factors are important in determining the success of in vitro fertilization (IVF). The results of this study suggest that the SCD test may more accurately evaluate the correlation between IVF clinical outcomes and male infertility. Male infertility due to DFI should be suspected when IVF results are poor despite normal semen findings based on the WHO criteria. High DFI (≥ 30%) caused a low blastocyst development rate following intracytoplasmic sperm injection. Therefore, evaluation with a general semen test based on the WHO criteria should be regarded as a qualitative evaluation of all factors other than semen volume and normal morphology. Patients who satisfied the WHO criteria in terms of concentration, total sperm count, and motility had a significantly lower DFI than those who did not satisfy the criteria. In contrast, motility and normal morphology decreased as the DFI increased. ![]() ![]() The subjects had a mean sperm DFI of 15.3% ± 12.6%, and the DFI increased with age. The WHO criteria were set as the cutoff values for each of the following factors: semen volume, concentration, total sperm count, motility, and normal morphology, and compared with the DFI results. Sperm chromatin dispersion (SCD) and general semen tests were conducted in accordance with the WHO 2010 guidelines, and correlations between the two tests were investigated. In addition, we examined whether DFI is a reliable parameter associated with in vitro fertilization (IVF) outcomes. We analyzed the sperm DNA fragmentation index (DFI) and general semen test based on the World Health Organization (WHO) criteria and compared the two tests using semen factors. ![]()
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